In the Valliant Group you get hands-on experience with a variety of techniques:
- organic and/or inorganic synthesis
- chemical biology
- drug discovery
Our group typically has 1-3 PDF, 8-10 graduate students, 2 biologists, and a laboratory manager.
Independently and as part of international collaborations, we have been involved in creating several compound discovery tools, synthesis strategies and novel agents in the field of molecular imaging and radiotherapy. Some of our success stories include:
- ultrasound molecular imaging using targeted microbubbles (Angew. Chem. Int. Ed. 2014, 53, 6459-6463).
- new carborane synthesis methods (Angew. Chem. 2014, 53, 5156-5160).
- dendrimer based molecular imaging probes (collaboration with professor Alex Adronov) (Biomacromolecules. 2015; 16, 3033-3041).
- the development and application of the SAAC ligand for the preparation of peptide targeted radiopharmaceuticals (Bioconj. Chem. 2004, 15, 128-136).
- using Tc and Re complexes in parallel for correlating fluorescence and radioimaging (Nucl. Med. Biol. 2008, 35, 159-169; J. Am. Chem. Soc. 2004, 126, 8598-8599)
- preparation and in vitro investigations of 18F-labelled compounds (J. Med. Chem. 2006, 49, 1466-1474)
- development of the flurous labelling method for the preparation and purification of radiolabelled compounds in high purity and specific activity (J. Org. Chem., 2008, 73, 8236-8243).