Publications – Peer Reviewed

PEER REVIEWED PUBLICATIONS (2011-PRESENT)

2017

Nagina Amir, David Green, Jeff Kent, Yun Xiang, Ivan Gorelikov, Minseok Seo, Megan Blacker, Nancy Janzen, Shannon Czorny, John F. Valliant, Naomi Matsuura. 18F-Labeled perfluorocarbon droplets for positron emission tomography imaging.  Nucl. Med. Biol. 2017; 54:27-33. DOI: 10.1016/j.nucmedbio.2017.07.001.

Vincent Bouvet, Melinda Wuest, Justin J. Bailey, Cody Bergman, Nancy Janzen, John F. Valliant, and Frank Wuest.Targeting prostate-specific membrane antigen (PSMA) with 18F-labeled compounds: The influence of prosthetic groups on tumor uptake and clearance profile. Mol. Imaging Biol. 2017; DOI: 10.1007/s11307-017-1102-x.

Abdolreza Yazdani, Nancy Janzen, Shannon Czorny, Robert Ungard, Tanya Miladinovic, Gurmit Singh,  and John F. Valliant. Preparation of tetrazine-containing [2 + 1] complexes of 99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels-Alder chemistry. Dalton Trans. 2017; DOI: 10.1039/c7dt01497j.

Joseph A. Ioppolo, Deanna Caldwell, Omid Beiraghi, Lisset Llano, Megan Blacker, John F. Valliant, Paul J. Berti.  67Ga-labelled deferoxamine derivatives for imaging bacterial infection: preparation and screening of functionalized siderophore complexes. Nucl. Med. Biol. 2017; 52:32-41. DOI: 10.1016/j.nucmedbio.2017.05.010.

Aimen Zlitni, Melissa Yin, Nancy Janzen, Samit Chatterjee, Ala Lisok, Kathleen L. Gabrielson, Sridhar Nimmagadda, Martin G. Pomper, F. Stuart Foster, and John F.Valliant.  Development of Prostate Specific Membrane Antigen Targeted Ultrasound Microbubbles Using Bioorthogonal Chemistry. PLoS One 2017; 12(5): e0176958 DOI: 10.1371/journal.pone.0176958.

Abdolreza Yazdani, Nancy Janzen, Shannon Czorny, John F. Valliant.* Technetium(I) Complexes of Bathophenanthroline Disulfonic Acid. Inorg. Chem. 2017; 56(5):2958–2965. DOI: 10.1021/acs.inorgchem.6b03058.

Holly A. Bilton, Zainab Ahmad, Nancy Janzen, Shannon Czorny, John F. Valliant.* Preparation and Evaluation of 99mTc-labeled tridentate chelates for pre-targeting using bioorthogonal chemistry. J. Visual. Exp. 2017. 120: e55188. DOI: 10.3791/55188.

Salma Al-Karmi, Silvia A. Albu, Alyssa Vito, Nancy Janzen, Shannon Czorny, Laura Banevicius, Max Nanao, Jon Zubieta, Alfredo Capretta,* John F. Valliant.* Preparation of a 18F-Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species. Chem. Eur. J. 2017; 23(2):254-258.  DOI: 10.1002/chem.201604473.

2016

Glenn Bauman, Peter Martin, Jonathan Thiessen, Reggie Taylor, Madeleine Moussa, Irina Rachinsky, Zahra Kassam, Joseph Chin, Stephen Pautler, T-Y Lee, John Valliant, Aaron Ward.   [18F]-DCFPyL PET/MRI for localization of dominant intra-prostatic foci: first experience.  Eur. Urol. Focus  (Oct., 2016)  DOI: 10.1016/j.euf.2016.10.002

Salma Al-Karmi, Silvia A. Albu, Alyssa Vito, Nancy Janzen, Shannon Czorny, Laura Banevicius, Max Nanao, Jon Zubieta, Alfredo Capretta,* John F. Valliant.* Preparation of a 18F-Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species. Chem. Eur. J. 2017; 23(2):254-258. DOI: 10.1002/chem.201604473.

Alyssa Vito, Hussain Alarabi, Shannon Czorny, Omid Beiraghi, Jeff Kent, Nancy Janzen, Afaf R. Genady, Salma A. Al-Karmi, Stephanie Rathmann, Zoya Naperstkow, Megan Blacker, Lisset Llano, Paul J. Berti and John F. Valliant.* A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. PLoS One. 2016; 11(12):e016745. DOI: 10.1371/journal.pone.0167425.

Abdolreza Yazdani, Holly Bilton, Alyssa Vito, Afaf R. Genady, Stephanie M. Rathmann, Zainab Ahmad, Nancy Janzen, Shannon Czorny, Brian M. Zeglis, Lynn C. Francesconi, John F. Valliant.* A Bone-Seeking Trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines. J. Med. Chem. 2016; 59(20):9381-9389.  DOI: 10.1021/acs.jmedchem.6b00938.

John F. Valliant.* A Bridge Not Too Far. Linking Disciplines Through Molecular Imaging Probes. J. Nucl. Med. Technol. 2016:44(3):173-183. DOI: 10.2967/jnumed.109.068312.

Stephanie M. Rathmann, Nancy Janzen, John F. Valliant.* Synthesis, radiolabelling and biodistribution studies of triazole derivatives for targeting melanoma. Can. J. Chem. 2016; 94(9): 773-780. DOI: 10.1139/cjc-2016-0239

Lukas P. Sadowski, Patricia E. Edem, John F. Valliant,* Alex Adronov.* Synthesis of Polyester Dendritic Scaffolds for Biomedical Applications. Macromol. Biosci. 2016; 16(10):1475-1484. DOI: 10.1002/mabi.201600154.

Vincent Bouvet, Melinda Wuest, Hans-Soenke Jans, Nancy Janzen, Afaf R. Genady, John F. Valliant, Francois Bernard, Frank Wuest.* Automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models. Eur J NMMI Res. 2016; 6(1):1-15. DOI: 10.1186/s13550-016-0195-6.

Ole Tietz, James Dzandzi, Atul Bhardwaj, John F. Valliant, Frank Wuest.* Design and synthesis of [125I]Pyricoxib: A novel 125I-labeled cyclooxygenase-2 (COX-2) inhibitors. Bioorg. Med. Chem. Lett. 2016; 26(6):1516-1520. DOI: 10.1016/j.bmcl.2016.02.029.

Afaf Genady, Nancy Janzen, Laura Banevicius, Mahmoud El-Gamal, Mohamed El Zaria, John Valliant.* Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules that Target Prostate Specific Membrane Antigen (PSMA) for Combined Radiotherapy and Immunotherapy. J. Med. Chem. 2016;59(6):2660–2673. DOI: 10.1021/acs.jmedchem.5b01881.

Rosalyn A. Juergens,* Katherine A. Zukotynski, Amit Singnurkar, Denis P. Snider, John F. Valliant, Karen Y. Gulenchyn. Imaging Biomarkers in Immunotherapy.  Biomarkers Cancer. 2016; 8(S2):1-13. DOI: 10.4137/BIC.S31805.

Silvia A. Albu, Salma A. Al-Karmi, James P.K. Dzandzi, Aimen Zlitni, Denis Beckford-Vera, Alyssa Vito, Megan Blacker, Nancy Janzen, Ramesh M. Patel, Alfredo Capretta, John, F. Valliant.* 125I-Tetrazines and Inverse-Electron-Demand Diels-Alder Chemistry:  A Convenient Radioiodination Strategy for Biomolecular Labeling, Screening and Biodistribution Studies.  Bioconjugate Chem. 2016; 27(1):207-216.  DOI: 10.1021/acs.bioconjchem.5b00609.

2015

Schaffer, P.; Benard, F.; Bernstein, A.; Buckley, K.; Celler, A.; Cockburn, N.; Corsaut, J.; Dodd, M.; Economou, C.; Eriksson, T.; Frontera, M.; Hanemaayer, V.; Hook, B.; Klug, J.; Kovacs, M.; Prato, F.S.; McDiarmid, S.; Ruth, T.J.; Shanks, C.; Valliant, J.F.; Zeisler, S.; Zetterberg, U.; Zavodszky, P.A. Direct Production of 99mTc via 100Mo(p,2n) on Small Medical Cyclotrons. Physics Procedia. 2015; 66(23): 383-395.

Stuart A. McNelles, Spencer D. Knight, Nancy Janzen, J.F. Valliant*, Alex Adronov.* Synthesis, Radiolabeling, and In-Vivo Imaging of PEGylated High-Generation Polyester Dendrimers. Biomacromolecules. 2015; 16(9):3033-3041.

James P. K. Dzandzi, Denis R. Beckford Vera, Afaf R. Genady, Silvia A. Albu, Louise J. Eltringham-Smith, Alfredo Capretta, William P. Sheffield, John F. Valliant. Fluorous Analogue of Chloramine-T: Preparation, X-ray Structure Determination and Use as an Oxidant for Radioiodination and s-Tetrazine Synthesis. J. Org. Chem. 2015; 80(14):7117-7125.

Afaf R. Genady, Joanne Tan, Mohamed E. El-Zaria, Aimen Zlitni, Nancy Janzen, John F. Valliant. Synthesis, Characterization and Radiolabeling of Carborane-Functionalized Tetrazines for Use in Inverse Electron Demand Diels-Alder Ligation Reactions. J. Organomet. Chem. 2015; 204-213.

Nilasha Banerjee, T. Robert Wu, Jason Chio, Ryan Kelly, Karin A. Stephenson, John Forbes, Christine Allen, John F. Valliant, Reina Bendayan. 125I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells Nuc. Med. Biol. 2015; 42(3)274-282.

Abdolreza Yazdani, Nancy Janzen, Laura Banevicius, Shannon Czorny, John F. Valliant. Imidazole-based [2+1] Re(I)/99mTc(I) Complexes as Isostructural Nuclear and Optical Probes. Inorg. Chem. 2015; 54(4):1728-1736.

2014

John F. Valliant, Patricia Edem, Shannon Czorny. Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B. J. Med. Chem. 2014; 57(22):9564‑9577.

James P. K. Dzandzi, Denis R. Beckford Vera, John F. Valliant.* A Hybrid Solid-Fluorous Phase Radioiodination and Purification Platform. J. Labelled Comp. Radiopharm. 2014; 57(9):551–557.

Mohamed E. El-Zaria, Kunal Keskar, Afaf R. Genady, Joseph A. Ioppolo, James McNulty, John F. Valliant. High Yielding Synthesis of Carboranes Under Mild Conditions Using a Homogeneous Silver(I) Catalyst. Direct Evidence of a Bimetallic Intermediate. Angew. Chem. Int. Ed. 2014; 53(20):5156-5160.

Aimen Zlitni, Nancy Janzen, F. Stuart Foster, John F. Valliant.* Catching Bubbles. Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse Electron Demand Diels-Alder Chemistry. Angewandte Chemie. 2014; 53(25):6459-6463.

Dong Hyun Kim, Megan Blacker, John F. Valliant.* Preparation and Evaluation of Fluorine-18 Labeled Insulin as a Molecular Imaging Probe for Studying Insulin Receptor Expression in Tumors. J. Med. Chem, 2014; 57(9):3678-3686.

Mohamed E. El-Zaria, Afaf R. Genady, Nancy Janzen, Christina I. Petlura, Denis R. Beckford Vera, John F. Valliant.* Preparation and Evaluation of Carborane-Derived Inhibitors of Prostate Specific Membrane Antigen (PSMA). Dalton Trans. 2014; 43(13):4911-5232.

Michael P. Coogan, Robert P. Doyle, John F. Valliant, John W. Babich, Jon Zubieta. Single amino acid chelate complexes of the M(CO)3+ core for correlating fluorescence and radioimaging studies (M = 99mTc or Re). J. Labelled Comp. Radiopharm. 2014; 57(4):255-261.

2013

Tamil Selvi Pitchumony, Laura Banevicius, Nancy Janzen, Jon Zubieta, John F. Valliant.* Isostructural Nuclear and Luminescent Probes Derived From Stabilized [2+1] Re(I)/Tc(I) Organometallic Complexes. Inorg. Chem. 2013; 52(23):13521-13528.

Antonio Toppino, Afaf R. Genady, Mohamed E. El-Zaria, James Reeve, Fargol Mostofian, Jeff Kent, John F. Valliant* High Yielding Preparation of Dicarba-closo-dodecaboranes Using a Silver(I) Mediated Dehydrogenative Alkyne-Insertion Reaction. Inorg. Chem. 2013; 52:8743-8749.

Kelly E. Henry, Rebeca G. Balasingham, Anthony R. Vortherms, James A. Platts, Michael P. Coogan, Jon Zubieta, Robert P. Doyle, John F. Valliant.* Emission wavelength variation with changes in excitation in a Re(i)-bisthiazole ligand complex that breaks the Kasha-Vavilov rule. Chemical Science 2013; 4:2490-2495.

2012

Mohamed El-Zaria, Nancy Janzen, John F. Valliant.* Room Temperature Synthesis of Re(I) and Tc(I) Metallocarboranes. Organometallics 2012; 31:5940-5949.

Mohamed E. El-Zaria, Nancy Janzen, Megan Blacker, John F. Valliant.* Synthesis, Characterization, and Biodistribution of Radiodinated C-Hydroxy-Carboranes. Chem. Eur. J. 2012; 18:11071-11078.

Anika Louie, Laura E. Harrington, John F. Valliant.* The Preparation and Characterization of Functionalized Carboranes and Re/Tc-Metallocarboranes as Platforms for Developing Molecular Imaging Probes: Structural and Cage Isomerism Studies. Inorg. Chim. Acta. 2012; 389:159-167.

Alla Darwish, Megan Blacker, Nancy Janzen, Stephanie M. Rathmann, Shannon K. Czorny, Shawn M. Hillier, John L. Joyal, John W. Babich, John F. Valliant.* Triazole Appending Agent (TAAG): A New Synthon for Preparing Iodine-Based Molecular Imaging and Radiotherapy Agents. Med. Chem. Lett. 2012; 3:313-316.

Ryan W. Simms, Patrick W. Causey, Darren M. Weaver, Chitra Sundararajan, Karin A. Stephenson, John F. Valliant.* Preparation of Technetium-99m Bifunctional Chelate Complexes Using a Microfluidic Reactor: A Comparative Study with Conventional and Microwave Labelling Methods. J. Labelled Comp. Rad. 2012; 55:18-22.

Ryan W. Simms, Dong Hyun Kim, Darren M. Weaver, Chitra Sundararajan, Megan Blacker, Karin A. Stephenson, John F. Valliant,* Emulsion Reactors: A New Technique for the Preparation of Molecular Imaging Probes. Chem. Eur J. 2012; 18:6746-6749.

2011

Neva Lazarova, Patrick W. Causey, Jennifer A. Lemon, Shannon K. Czorny, John R. Forbes, Aimen Zlitni, Afaf Genady, Stuart F. Foster, John F. Valliant.* The Synthesis, Magnetic Purification and Evaluation of 99m Tc-labeled Microbubbles. Nucl. Med. Biol. 2011; 38:1111-1118.

Jacqueline A. Gleave, John F. Valliant, Laurie Doering.* 99mTc-based Imaging of Transplanted Neural Stem Cells and Progenitor Cells. J. Nucl. Med. Technol. 2011; 39:114-120.

Henrik Braband, Yuji Tooyama, Thomas Fox, Ryan Simms, John Forbes, John F. Valliant, Roger Alberto.* fac-[TcO3(tacn)]+: A Versatile Precursor for the Labelling of Pharmacophores, Amino Acids and Carbohydrates through a New Ligand-Centred Labelling Strategy. Chem. Eur J. 2011; 17:12967-12974.

Anika S. Louie, Neil Vasdev, John F. Valliant.* Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors. J. Med. Chem. 2011; 54:3360-3367.

Justin W. Hicks, Laura E. Harrington, John F. Valliant.* Fluorous Ligand Capture (FLC): A Chemoselective Solution-phase Strategy for Isolating 99mTc-labelled Compounds in High Effective Specific Activity. Chem. Commun. 2011; 47:7518-7520.

Amanda C. Donovan, John F. Valliant.* Preparation and Evaluation of Reagents for Tagging Amino and Thiol Groups with Fluorous Stannanes. A Convenient Method for Producing Radioiodinated Compounds in High Effective Specific Activity. J. Labelled Comp. Rad. 2011; 54:65-71.